Nature could provide the answer for blindness caused by diabetes, say experts
Mother Nature could have
the answer to treat several causes of blindness, according to a ground-breaking
study involving scientists from the University of Surrey and the Eugene and
Marilyn Glick Eye Institute at Indiana University School of Medicine in the
USA.
The scientists have found
and tested compounds from a group of plants that could possibly be used to
treat the causes of degenerative eye diseases such as proliferative diabetic
retinopathy.
This abnormal growth of
new blood vessel cells in the eye is linked to a number of types of blindness,
including in premature babies (retinopathy of prematurity), diabetics
(proliferative diabetic retinopathy) and older adults (wet age-related macular
degeneration).
In a paper published by
the American Chemical Society, the University of Surrey, together with experts
from Indiana University in America and Kingston University, detailed their
testing of naturally occurring homoisoflavonoids found in the Hyacinthaceae
plant family and their synthetic derivatives.
The team tested how well
these compounds were able to stop the growth of new blood vessels and isolated
several active compounds. One synthetic derivative in particular could be used
to develop future treatments. Further work is continuing to synthesize more
related compounds.
According to Great Ormond
Street Hospital, retinopathy of prematurity affects around 20 per cent of
premature babies and mainly occurs in those who are born before week 32 of
pregnancy or weigh less than 1500g.
Professor Dulcie
Mulholland, Head of Department of Chemistry at the University of Surrey, said:
"It goes without saying that losing your eyesight is a devastating
experience. We believe that our results hint at possible future treatments for
many degenerative eye conditions and it appears that nature still has many secrets
to reveal."
Professor Tim Corson,
Director of Basic and Translational Research at the Eugene and Marilyn Glick
Eye Institute, added: "Existing therapies for these diseases must be
injected into the eye, and do not work in all patients. Our findings are a
first step towards therapies that might avoid these shortcomings."
Dr. Sianne Schwikkard,
School of Life Sciences, Pharmacy and Chemistry, Kingston University, London
(and a former Daphne Jackson Fellow 2014—2016, based at the University of
Surrey and sponsored by the Royal Society of Chemistry) said: "The
discovery of new and innovative treatments from natural sources for
life-altering diseases has huge potential. This work has produced a real
opportunity to further collaboration and has the potential to bring new breakthroughs
in the treatment of degenerative eye-diseases."
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